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DEFINITION CTI (computer-telephony integration) Posted by: Margaret Rouse WhatIs.com Contributor(s): Koen DeWitte and many others CTI (computer-telephony integration), or sometimes simply "computer telephony," is the use of computers to manage telephone calls. The term is used in describing the computerized services of call centers, such as those that direct your phone call to the right department at a business you"re calling. It"s also sometimes used to describe the ability to use your personal computer to initiate and manage phone calls (in which case you can think of your computer as your personal call center).